Dr. Dina R. Mody
HPV test
- DNA HPV test will fail.
- BD (Oncolarity) is for a screening test.
- genotype 66 high risk.
- False-negative 10%. DNA copy number is the cause.
- False positive cross reactivity 0.35%, 0.71% Aptima and Cobas. (one quarter)
Dr. Sneige
Immunostain in breast
- Reduced and diminished myoepithelial cells, phenotypic alteration, SMA remain but others lost.
- Any positivity for MEC favors in situ than invasive.
- Metaplastic carcinoma and fibromatosis like
- TTF-1 2% positive in breast cancer.
Dr. Prieto
Cutaneous lymphoma
- Mycosis fungoides cell are atypical 7 fold folding nuclear membrane
- CD4 predominant than CD8
- Mycosis fungoides with large cell transformation
- CD8 mycosis fungoides
- Granulomatous MF
- Immunohistochemistry marker related to TX
- CD25, CD30
Again Dr. Mody
- Super D specimen preparation
- Guideline will be released.
Dr. Medeiros, Hodgkin lymphomas
- Popcorn, not poped
- Hodgkin lymphoma cells were renamed.
- LP cells, Lacunar cells, RS + mononuclear variants/anaplastic variants
Dr. El-Naggar H&N cancer
- HPV nasopharyngeal carcinoma
- Young caucasian male
- H&N is different from anogenital area
Dr. Moran
- Neuroendocrine carcinoma in lung
- Do not follow the WHO without own justification
- Mitoses count is not rigorous measurement. eyepiece diameters, hotspot vs random
- Arrigoni criteria 1974 was 5-10 mitosis per 10 HPF
Dr. Jihun Kim colitis
Yersinia
- Suppurative granulomas
- Heaped up mass-like mucosal thickening
- Superficial ileocecal lesion
- Lymphoid follicles
NSAID-induced enteropathy
- Radiating fibrosis around the ulcer
- Diaphragm-like stricture
Nivolumab-induced colitis
Dr. Moran Salivary-gland type tumors of the lung
- Central intrabronchial mass
- Frozen diagnosis important sleeve or total pneumonectomy
- Adenosquamous is different with mucoepidermoid
- Mucoepidermoid m/c and children
- MAML2 translocation
- Acinic cell carcinoma gold standard is EM
Dr. Sneige Breast cancer biomarkers
- ER test SP1 Scandle https://www.cbc.ca/news/canada/newfoundland-labrador/lab-mistakes-poor-oversight-flagged-in-n-l-breast-cancer-inquiry-1.793504
- Fixation time 6hr - 72 hr
- False negative
- Control tissues
- HER2 test 2018 guidelines
- OncotypeDX NEJM 2018 intermediated group can skip chemotherapy
Dr. Prieto Cutaneous mesenchymal tumors
- Dermatofibroma vs Dermatofibrosarcoma protuberance
- Epithelioid fibrous histiocytoma
- Resembling melanoma
- Angiomatoid fibrous histiocytoma
- Translocation EWSR1, FUS, CREB1, ATF1
- Atypical fibroxanthoma
- Solitary lesion on sun-exposed skin
- Elderly adult
- Neurothekeoma
Dr. Medeiros Marginal zone lymphomas
- There category vs two cathegory (feat Dr. In-sun Kim)
- Colonization in follicles
- Cause of disease infection
- H. pylori
- HCV
- Campylobacter jejuni
- Boring immunophenotype, important translocations
- API2 and MALT1
- IGH and MALT1
- FOXP1 and MALT1
- BCL10 and IGH
- Large cell transformaion
- Splenic marginal zone lymphoma
- Systemic involvement, bone marrow, peripheral blood
Dr. El-Naggar
- Salivary gland tumor
- Ductal carcinoma
- Homology with breast, prostate
- Testosterone, Androgen, and Steroid
- Androgen receptor, Glucocorticoid receptor
- Androgen receptor splicing variant: constitutive activation
Dr. Kyu-Rae Kim
- Progestin treatment failure
- Myometrial invasion, basal layer involvement
- No guideline for residual tumor
