class: center, middle, inverse, title-slide # BRCA mutation in pancancer ### Jun Kang ### 2021.10.20 --- class: center # BRCA mutation from cbioportal <img src="BRCApancancer_files/figure-html/unnamed-chunk-2-1.png" width="100%" /> --- # Mutation type |MutationType | n| |:-----------------|-----:| |Frame shift | 113| |In_Frame_Del | 8| |Missense_Mutation | 1038| |Nonsense_Mutation | 97| |Splice | 54| |Wild type | 58413| --- class: center # Frame shift <img src="BRCApancancer_files/figure-html/unnamed-chunk-4-1.png" width="100%" /> --- class: center # Nonsense <img src="BRCApancancer_files/figure-html/unnamed-chunk-5-1.png" width="100%" /> --- class: center # Splice <img src="BRCApancancer_files/figure-html/unnamed-chunk-6-1.png" width="100%" /> --- class: center # Missense <img src="BRCApancancer_files/figure-html/unnamed-chunk-7-1.png" width="100%" /> --- # BRCA HRD and LOH in non-small cell carinoma [1] ![](img/HRDLOH.png) --- # References [1] J. Remon, B. Besse, A. Leary, et al. "Somatic and Germline BRCA 1 and 2 Mutations in Advanced NSCLC From the SAFIR02-Lung Trial". In: _JTO Clinical and Research Reports_ 1.3 (9. 01, 2020). ISSN: 2666-3643, 2666-3643.